KEGG   Homo sapiens (human): 4638
Entry
4638              CDS       T01001                                 
Symbol
MYLK, AAT7, KRP, MLCK, MLCK1, MLCK108, MLCK210, MMIHS, MMIHS1, MSTP083, MYLK-L, MYLK1, smMLCK
Name
(RefSeq) myosin light chain kinase
  KO
K00907  myosin-light-chain kinase [EC:2.7.11.18]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04270  Vascular smooth muscle contraction
hsa04371  Apelin signaling pathway
hsa04510  Focal adhesion
hsa04611  Platelet activation
hsa04810  Regulation of actin cytoskeleton
hsa04921  Oxytocin signaling pathway
hsa04971  Gastric acid secretion
Network
nt06528  Calcium signaling
  Element
N01648  Ca2+/CAM-CAMK signaling pathway
Disease
H00801  Familial thoracic aortic aneurysm and dissection
H01869  Megacystis microcolon intestinal hypoperistalsis syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    4638 (MYLK)
   04020 Calcium signaling pathway
    4638 (MYLK)
   04022 cGMP-PKG signaling pathway
    4638 (MYLK)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    4638 (MYLK)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    4638 (MYLK)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    4638 (MYLK)
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    4638 (MYLK)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    4638 (MYLK)
  09154 Digestive system
   04971 Gastric acid secretion
    4638 (MYLK)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    4638 (MYLK)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     4638 (MYLK)
Protein kinases [BR:hsa01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   4638 (MYLK)
SSDB
Motif
Pfam: I-set Ig_3 ig Ig_2 Pkinase 23ISL V-set PK_Tyr_Ser-Thr C2-set_2 fn3 Ig_4 Invasin_D3 Kinase-like Kdo DUF5898 Pur_ac_phosph_N AvrM_N
Other DBs
NCBI-GeneID: 4638
NCBI-ProteinID: NP_444253
OMIM: 600922
HGNC: 7590
Ensembl: ENSG00000065534
UniProt: Q15746
Structure
Position
3:complement(123610049..123884332)
AA seq 1914 aa
MGDVKLVASSHISKTSLSVDPSRVDSMPLTEAPAFILPPRNLCIKEGATAKFEGRVRGYP
EPQVTWHRNGQPITSGGRFLLDCGIRGTFSLVIHAVHEEDRGKYTCEATNGSGARQVTVE
LTVEGSFAKQLGQPVVSKTLGDRFSAPAVETRPSIWGECPPKFATKLGRVVVKEGQMGRF
SCKITGRPQPQVTWLKGNVPLQPSARVSVSEKNGMQVLEIHGVNQDDVGVYTCLVVNGSG
KASMSAELSIQGLDSANRSFVRETKATNSDVRKEVTNVISKESKLDSLEAAAKSKNCSSP
QRGGSPPWAANSQPQPPRESKLESCKDSPRTAPQTPVLQKTSSSITLQAARVQPEPRAPG
LGVLSPSGEERKRPAPPRPATFPTRQPGLGSQDVVSKAANRRIPMEGQRDSAFPKFESKP
QSQEVKENQTVKFRCEVSGIPKPEVAWFLEGTPVRRQEGSIEVYEDAGSHYLCLLKARTR
DSGTYSCTASNAQGQLSCSWTLQVERLAVMEVAPSFSSVLKDCAVIEGQDFVLQCSVRGT
PVPRITWLLNGQPIQYARSTCEAGVAELHIQDALPEDHGTYTCLAENALGQVSCSAWVTV
HEKKSSRKSEYLLPVAPSKPTAPIFLQGLSDLKVMDGSQVTMTVQVSGNPPPEVIWLHNG
NEIQESEDFHFEQRGTQHSLCIQEVFPEDTGTYTCEAWNSAGEVRTQAVLTVQEPHDGTQ
PWFISKPRSVTASLGQSVLISCAIAGDPFPTVHWLRDGKALCKDTGHFEVLQNEDVFTLV
LKKVQPWHAGQYEILLKNRVGECSCQVSLMLQNSSARALPRGREPASCEDLCGGGVGADG
GGSDRYGSLRPGWPARGQGWLEEEDGEDVRGVLKRRVETRQHTEEAIRQQEVEQLDFRDL
LGKKVSTKTLSEDDLKEIPAEQMDFRANLQRQVKPKTVSEEERKVHSPQQVDFRSVLAKK
GTSKTPVPEKVPPPKPATPDFRSVLGGKKKLPAENGSSSAETLNAKAVESSKPLSNAQPS
GPLKPVGNAKPAETLKPMGNAKPAETLKPMGNAKPDENLKSASKEELKKDVKNDVNCKRG
HAGTTDNEKRSESQGTAPAFKQKLQDVHVAEGKKLLLQCQVSSDPPATIIWTLNGKTLKT
TKFIILSQEGSLCSVSIEKALPEDRGLYKCVAKNDAGQAECSCQVTVDDAPASENTKAPE
MKSRRPKSSLPPVLGTESDATVKKKPAPKTPPKAAMPPQIIQFPEDQKVRAGESVELFGK
VTGTQPITCTWMKFRKQIQESEHMKVENSENGSKLTILAARQEHCGCYTLLVENKLGSRQ
AQVNLTVVDKPDPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYSIEIWDSANKTWKE
LATCRSTSFNVQDLLPDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDD
DEKEPEVDYRTVTINTEQKVSDFYDIEERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSA
KEKENIRQEISIMNCLHHPKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTER
ECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCVNKTGTRIKLIDFGLARRLENAGSLKV
LFGTPEFVAPEVINYEPIGYATDMWSIGVICYILVSGLSPFMGDNDNETLANVTSATWDF
DDEAFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYM
ARRKWQKTGNAVRAIGRLSSMAMISGLSGRKSSTGSPTSPLNAEKLESEEDVSQAFLEAV
AEEKPHVKPYFSKTIRDLEVVEGSAARFDCKIEGYPDPEVVWFKDDQSIRESRHFQIDYD
EDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELIVETMEEGEGEGEEEEE
NT seq 5745 nt   +upstreamnt  +downstreamnt
atgggggatgtgaagctggttgcctcgtcacacatttccaaaacctccctcagtgtggat
ccctcaagagttgactccatgcccctgacagaggcccctgctttcattttgccccctcgg
aacctctgcatcaaagaaggagccaccgccaagttcgaagggcgggtccggggttaccca
gagccccaggtgacatggcacagaaacgggcaacccatcaccagcgggggccgcttcctg
ctggattgcggcatccgggggactttcagccttgtgattcatgctgtccatgaggaggac
aggggaaagtatacctgtgaagccaccaatggcagtggtgctcgccaggtgacagtggag
ttgacagtagaaggaagttttgcgaagcagcttggtcagcctgttgtttccaaaacctta
ggggatagattttcagctccagcagtggagacccgtcctagcatctggggggagtgccca
ccaaagtttgctaccaagctgggccgagttgtggtcaaagaaggacagatgggacgattc
tcctgcaagatcactggccggccccaaccgcaggtcacctggctcaagggaaatgttcca
ctgcagccgagtgcccgtgtgtctgtgtctgagaagaacggcatgcaggttctggaaatc
catggagtcaaccaagatgacgtgggagtgtacacgtgcctggtggtgaacgggtcgggg
aaggcctcgatgtcagctgaactttccatccaaggtttggacagtgccaataggtcattt
gtgagagaaacaaaagccaccaattcagatgtcaggaaagaggtgaccaatgtaatctca
aaggagtcgaagctggacagtctggaggctgcagccaaaagcaagaactgctccagcccc
cagagaggtggctccccaccctgggctgcaaacagccagcctcagcccccaagggagtcc
aagctggagtcatgcaaggactcgcccagaacggccccgcagaccccggtccttcagaag
acttccagctccatcaccctgcaggccgcaagagttcagccggaaccaagagcaccaggc
ctgggggtcctatcaccttctggagaagagaggaagaggccagctcctccccgtccagcc
accttccccaccaggcagcctggcctggggagccaagatgttgtgagcaaggctgctaac
aggagaatccccatggagggccagagggattcagcattccccaaatttgagagcaagccc
caaagccaggaggtcaaggaaaatcaaactgtcaagttcagatgtgaagtttccgggatt
ccaaagcctgaagtggcctggttcctggaaggcacccccgtgaggagacaggaaggcagc
attgaggtttatgaagatgctggctcccattacctctgcctgctgaaagcccggaccagg
gacagtgggacatacagctgcactgcttccaacgcccaaggccagctgtcctgtagctgg
accctccaagtggaaaggcttgccgtgatggaggtggccccctccttctccagtgtcctg
aaggactgcgctgttattgagggccaggattttgtgctgcagtgctccgtacgggggacc
ccagtgccccggatcacttggctgctgaatgggcagcccatccagtacgctcgctccacc
tgcgaggccggcgtggctgagctccacatccaggatgccctgccggaggaccatggcacc
tacacctgcctagctgagaatgccttggggcaggtgtcctgcagcgcctgggtcaccgtc
catgaaaagaagagtagcaggaagagtgagtaccttctgcctgtggctcccagcaagccc
actgcacccatcttcctgcagggcctctctgatctcaaagtcatggatggaagccaggtc
actatgactgtccaagtgtcagggaatccaccccctgaagtcatctggctgcacaatggg
aatgagatccaagagtcagaggacttccactttgaacagagaggaactcagcacagcctt
tgtatccaggaagtgttcccggaggacacgggcacgtacacctgcgaggcctggaacagc
gctggagaggtccgcacccaggccgtgctcacggtacaagagcctcacgatggcacccag
ccctggttcatcagtaagcctcgctcagtgacagcctccctgggccagagtgtcctcatc
tcctgcgccatagctggtgacccctttcctaccgtgcactggctcagagatggcaaagcc
ctctgcaaagacactggccacttcgaggtgcttcagaatgaggacgtgttcaccctggtt
ctaaagaaggtgcagccctggcatgccggccagtatgagatcctgctcaagaaccgggtt
ggcgaatgcagttgccaggtgtcactgatgctacagaacagctctgccagagcccttcca
cgggggagggagcctgccagctgcgaggacctctgtggtggaggagttggtgctgatggt
ggtggtagtgaccgctatgggtccctgaggcctggctggccagcaagagggcagggttgg
ctagaggaggaagacggcgaggacgtgcgaggggtgctgaagaggcgcgtggagacgagg
cagcacactgaggaggcgatccgccagcaggaggtggagcagctggacttccgagacctc
ctggggaagaaggtgagtacaaagaccctatcggaagacgacctgaaggagatcccagcc
gagcagatggatttccgtgccaacctgcagcggcaagtgaagccaaagactgtgtctgag
gaagagaggaaggtgcacagcccccagcaggtcgattttcgctctgtcctggccaagaag
gggacttccaagacccccgtgcctgagaaggtgccaccgccaaaacctgccaccccggat
tttcgctcagtgctgggtggcaagaagaaattaccagcagagaatggcagcagcagtgcc
gagaccctgaatgccaaggcagtggagagttccaagcccctgagcaatgcacagccttca
gggcccttgaaacccgtgggcaacgccaagcctgctgagaccctgaagccaatgggcaac
gccaagcctgccgagaccctgaagcccatgggcaatgccaagcctgatgagaacctgaaa
tccgctagcaaagaagaactcaagaaagacgttaagaatgatgtgaactgcaagagaggc
catgcagggaccacagataatgaaaagagatcagagagccaggggacagccccagccttc
aagcagaagctgcaagatgttcatgtggcagagggcaagaagctgctgctccagtgccag
gtgtcttctgaccccccagccaccatcatctggacgctgaacggaaagaccctcaagacc
accaagttcatcatcctctcccaggaaggctcactctgctccgtctccatcgagaaggca
ctgcctgaggacagaggcttatacaagtgtgtagccaagaatgacgctggccaggcggag
tgctcctgccaagtcaccgtggatgatgctccagccagtgagaacaccaaggccccagag
atgaaatcccggaggcccaagagctctcttcctcccgtgctaggaactgagagtgatgcg
actgtgaaaaagaaacctgcccccaagacacctccgaaggcagcaatgccccctcagatc
atccagttccctgaggaccagaaggtacgcgcaggagagtcagtggagctgtttggcaaa
gtgacaggcactcagcccatcacctgtacctggatgaagttccgaaagcagatccaggaa
agcgagcacatgaaggtggagaacagcgagaatggcagcaagctcaccatcctggccgcg
cgccaggagcactgcggctgctacacactgctggtggagaacaagctgggcagcaggcag
gcccaggtcaacctcactgtcgtggataagccagaccccccagctggcacaccttgtgcc
tctgacattcggagctcctcactgaccctgtcctggtatggctcctcatatgatgggggc
agtgctgtacagtcctacagcatcgagatctgggactcagccaacaagacgtggaaggaa
ctagccacatgccgcagcacctctttcaacgtccaggacctgctgcctgaccacgaatat
aagttccgtgtacgtgcaatcaacgtgtatggaaccagtgagccaagccaggagtctgaa
ctcacaacggtaggagagaaacctgaagagccgaaggatgaagtggaggtgtcagatgat
gatgagaaggagcccgaggttgattaccggacagtgacaatcaatactgaacaaaaagta
tctgacttctacgacattgaggagagattaggatctgggaaatttggacaggtctttcga
cttgtagaaaagaaaactcgaaaagtctgggcagggaagttcttcaaggcatattcagca
aaagagaaagagaatatccggcaggagattagcatcatgaactgcctccaccaccctaag
ctggtccagtgtgtggatgcctttgaagaaaaggccaacatcgtcatggtcctggagatc
gtgtcaggaggggagctgtttgagcgcatcattgacgaggactttgagctgacggagcgt
gagtgcatcaagtacatgcggcagatctcggagggagtggagtacatccacaagcagggc
atcgtgcacctggacctcaagccggagaacatcatgtgtgtcaacaagacgggcaccagg
atcaagctcatcgactttggtctggccaggaggctggagaatgcggggtctctgaaggtc
ctctttggcaccccagaatttgtggctcctgaagtgatcaactatgagcccatcggctac
gccacagacatgtggagcatcggggtcatctgctacatcctagtcagtggcctttccccc
ttcatgggagacaacgataacgaaaccttggccaacgttacctcagccacctgggacttc
gacgacgaggcattcgatgagatctccgacgatgccaaggatttcatcagcaatctgctg
aagaaagatatgaaaaaccgcctggactgcacgcagtgccttcagcatccatggctaatg
aaagataccaagaacatggaggccaagaaactctccaaggaccggatgaagaagtacatg
gcaagaaggaaatggcagaaaacgggcaatgctgtgagagccattggaagactgtcctct
atggcaatgatctcagggctcagtggcaggaaatcctcaacagggtcaccaaccagcccg
ctcaatgcagaaaaactagaatctgaagaagatgtgtcccaagctttccttgaggctgtt
gctgaggaaaagcctcatgtaaaaccctatttctctaagaccattcgcgatttagaagtt
gtggagggaagtgctgctagatttgactgcaagattgaaggatacccagaccccgaggtt
gtctggttcaaagatgaccagtcaatcagggagtcccgccacttccagatagactacgat
gaggacgggaactgctctttaattattagtgatgtttgcggggatgacgatgccaagtac
acctgcaaggctgtcaacagtcttggagaagccacctgcacagcagagctcattgtggaa
acgatggaggaaggtgaaggggaaggggaagaggaagaagagtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (9)   
   KEGG PATHWAY (9)   
Network (2)   
   KEGG NETWORK (2)   
Disease (5)   
   KEGG DISEASE (2)   
   OMIM (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (48)   
   KEGG ORTHOLOGY (1)   
   RefGene (32)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (10)   
   OC (1)   
Protein sequence (45)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (43)   
DNA sequence (142)   
   RefSeq(nuc) (46)   
   GenBank (48)   
   EMBL (48)   
3D Structure (6)   
   PDB (6)   
Protein domain (17)   
   Pfam (17)   
All databases (279)   

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