KEGG   Homo sapiens (human): 7525
Entry
7525              CDS       T01001                                 
Symbol
YES1, HsT441, P61-YES, Yes, c-yes
Name
(RefSeq) YES proto-oncogene 1, Src family tyrosine kinase
  KO
K05705  tyrosine-protein kinase Yes [EC:2.7.10.2]
Organism
hsa  Homo sapiens (human)
Pathway
hsa04520  Adherens junction
Drug target
Dasatinib (DG00714): D03658<JP> D06414<JP/US> D12609
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    7525 (YES1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hsa01001]
    7525 (YES1)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    7525 (YES1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     7525 (YES1)
Protein kinases [BR:hsa01001]
 Non-receptor tyrosine kinases
  SRC family
   7525 (YES1)
Membrane trafficking [BR:hsa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    7525 (YES1)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase SH2 SH3_1 SH3_9 SH3_2 Haspin_kinase SH3_10 zf-RING_14 ABC1 SH3_3
Other DBs
NCBI-GeneID: 7525
NCBI-ProteinID: NP_005424
OMIM: 164880
HGNC: 12841
Ensembl: ENSG00000176105
UniProt: P07947
Structure
Position
18:complement(721588..812753)
AA seq 543 aa
MGCIKSKENKSPAIKYRPENTPEPVSTSVSHYGAEPTTVSPCPSSSAKGTAVNFSSLSMT
PFGGSSGVTPFGGASSSFSVVPSSYPAGLTGGVTIFVALYDYEARTTEDLSFKKGERFQI
INNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRG
IFLVRESETTKGAYSLSIRDWDEIRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHY
TEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTT
KVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGSLLDFL
KEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARL
IEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNRE
VLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPG
ENL
NT seq 1632 nt   +upstreamnt  +downstreamnt
atgggctgcattaaaagtaaagaaaacaaaagtccagccattaaatacagacctgaaaat
actccagagcctgtcagtacaagtgtgagccattatggagcagaacccactacagtgtca
ccatgtccgtcatcttcagcaaagggaacagcagttaatttcagcagtctttccatgaca
ccatttggaggatcctcaggggtaacgccttttggaggtgcatcttcctcattttcagtg
gtgccaagttcatatcctgctggtttaacaggtggtgttactatatttgtggccttatat
gattatgaagctagaactacagaagacctttcatttaagaagggtgaaagatttcaaata
attaacaatacggaaggagattggtgggaagcaagatcaatcgctacaggaaagaatggt
tatatcccgagcaattatgtagcgcctgcagattccattcaggcagaagaatggtatttt
ggcaaaatggggagaaaagatgctgaaagattacttttgaatcctggaaatcaacgaggt
attttcttagtaagagagagtgaaacaactaaaggtgcttattccctttctattcgtgat
tgggatgagataaggggtgacaatgtgaaacactacaaaattaggaaacttgacaatggt
ggatactatatcacaaccagagcacaatttgatactctgcagaaattggtgaaacactac
acagaacatgctgatggtttatgccacaagttgacaactgtgtgtccaactgtgaaacct
cagactcaaggtctagcaaaagatgcttgggaaatccctcgagaatctttgcgactagag
gttaaactaggacaaggatgtttcggcgaagtgtggatgggaacatggaatggaaccacg
aaagtagcaatcaaaacactaaaaccaggtacaatgatgccagaagctttccttcaagaa
gctcagataatgaaaaaattaagacatgataaacttgttccactatatgctgttgtttct
gaagaaccaatttacattgtcactgaatttatgtcaaaaggaagcttattagatttcctt
aaggaaggagatggaaagtatttgaagcttccacagctggttgatatggctgctcagatt
gctgatggtatggcatatattgaaagaatgaactatattcaccgagatcttcgggctgct
aatattcttgtaggagaaaatcttgtgtgcaaaatagcagactttggtttagcaaggtta
attgaagacaatgaatacacagcaagacaaggtgcaaaatttccaatcaaatggacagct
cctgaagctgcactgtatggtcggtttacaataaagtctgatgtctggtcatttggaatt
ctgcaaacagaactagtaacaaagggccgagtgccatatccaggtatggtgaaccgtgaa
gtattagaacaagtggagcgaggatacaggatgccgtgccctcagggctgtccagaatcc
ctccatgaattgatgaatctgtgttggaagaaggaccctgatgaaagaccaacatttgaa
tatattcagtccttcttggaagactacttcactgctacagagccacagtaccagccagga
gaaaatttataa

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   OMIM (1)   
Drug (3)   
   KEGG DRUG (3)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (17)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (5)   
   OC (1)   
Protein sequence (21)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (19)   
DNA sequence (35)   
   RefSeq(nuc) (19)   
   GenBank (8)   
   EMBL (8)   
3D Structure (1)   
   PDB (1)   
Protein domain (11)   
   Pfam (11)   
All databases (96)   

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