KEGG   Homo sapiens (human): 4137
Entry
4137              CDS       T01001                                 
Symbol
MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, PPP1R103, TAU, Tau-PHF6, tau-40
Name
(RefSeq) microtubule associated protein tau
  KO
K04380  microtubule-associated protein tau
Organism
hsa  Homo sapiens (human)
Pathway
hsa04010  MAPK signaling pathway
hsa05010  Alzheimer disease
hsa05012  Parkinson disease
hsa05022  Pathways of neurodegeneration - multiple diseases
Network
nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
  Element
N00997  Mutation-caused aberrant Abeta to electron transfer in Complex I
N01018  Mutation-caused aberrant Abeta to anterograde axonal transport
N01403  Zn to anterograde axonal transport
N01414  Iron to anterograde axonal transport
Disease
H00057  Parkinson disease
H00058  Amyotrophic lateral sclerosis (ALS)
H00077  Progressive supranuclear palsy
H00078  Frontotemporal lobar degeneration
Drug target
Bepranemab: D12228
Flortaucipir (18F): D11210<US>
Gosuranemab: D11293
Hydromethylthionine (DG03014): D11384 D11427
Posdinemab: D12636
Semorinemab: D11687
Tilavonemab: D11840
Zagotenemab: D11533
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    4137 (MAPT)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    4137 (MAPT)
   05012 Parkinson disease
    4137 (MAPT)
   05022 Pathways of neurodegeneration - multiple diseases
    4137 (MAPT)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:hsa01009]
    4137 (MAPT)
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:hsa04131]
    4137 (MAPT)
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins [BR:hsa04812]
    4137 (MAPT)
Protein phosphatases and associated proteins [BR:hsa01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     4137 (MAPT)
Membrane trafficking [BR:hsa04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Selective cargos
    4137 (MAPT)
Cytoskeleton proteins [BR:hsa04812]
 Eukaryotic cytoskeleton proteins
  Microtubules
   Tubulin-binding proteins
    Microtubule-associated proteins (MAPs)
     4137 (MAPT)
SSDB
Motif
Pfam: Tubulin-binding Tmemb_cc2
Other DBs
NCBI-GeneID: 4137
NCBI-ProteinID: NP_058519
OMIM: 157140
HGNC: 6893
Ensembl: ENSG00000186868
UniProt: P10636
Structure
Position
17:45894554..46028334
AA seq 758 aa
MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
NT seq 2277 nt   +upstreamnt  +downstreamnt
atggctgagccccgccaggagttcgaagtgatggaagatcacgctgggacgtacgggttg
ggggacaggaaagatcaggggggctacaccatgcaccaagaccaagagggtgacacggac
gctggcctgaaagaatctcccctgcagacccccactgaggacggatctgaggaaccgggc
tctgaaacctctgatgctaagagcactccaacagcggaagatgtgacagcacccttagtg
gatgagggagctcccggcaagcaggctgccgcgcagccccacacggagatcccagaagga
accacagctgaagaagcaggcattggagacacccccagcctggaagacgaagctgctggt
cacgtgacccaagagcctgaaagtggtaaggtggtccaggaaggcttcctccgagagcca
ggccccccaggtctgagccaccagctcatgtccggcatgcctggggctcccctcctgcct
gagggccccagagaggccacacgccaaccttcggggacaggacctgaggacacagagggc
ggccgccacgcccctgagctgctcaagcaccagcttctaggagacctgcaccaggagggg
ccgccgctgaagggggcagggggcaaagagaggccggggagcaaggaggaggtggatgaa
gaccgcgacgtcgatgagtcctccccccaagactcccctccctccaaggcctccccagcc
caagatgggcggcctccccagacagccgccagagaagccaccagcatcccaggcttccca
gcggagggtgccatccccctccctgtggatttcctctccaaagtttccacagagatccca
gcctcagagcccgacgggcccagtgtagggcgggccaaagggcaggatgcccccctggag
ttcacgtttcacgtggaaatcacacccaacgtgcagaaggagcaggcgcactcggaggag
catttgggaagggctgcatttccaggggcccctggagaggggccagaggcccggggcccc
tctttgggagaggacacaaaagaggctgaccttccagagccctctgaaaagcagcctgct
gctgctccgcgggggaagcccgtcagccgggtccctcaactcaaagctcgcatggtcagt
aaaagcaaagacgggactggaagcgatgacaaaaaagccaagacatccacacgttcctct
gctaaaaccttgaaaaataggccttgccttagccccaaacaccccactcctggtagctca
gaccctctgatccaaccctccagccctgctgtgtgcccagagccaccttcctctcctaaa
tacgtctcttctgtcacttcccgaactggcagttctggagcaaaggagatgaaactcaag
ggggctgatggtaaaacgaagatcgccacaccgcggggagcagcccctccaggccagaag
ggccaggccaacgccaccaggattccagcaaaaaccccgcccgctccaaagacaccaccc
agctctggtgaacctccaaaatcaggggatcgcagcggctacagcagccccggctcccca
ggcactcccggcagccgctcccgcaccccgtcccttccaaccccacccacccgggagccc
aagaaggtggcagtggtccgtactccacccaagtcgccgtcttccgccaagagccgcctg
cagacagcccccgtgcccatgccagacctgaagaatgtcaagtccaagatcggctccact
gagaacctgaagcaccagccgggaggcgggaaggtgcagataattaataagaagctggat
cttagcaacgtccagtccaagtgtggctcaaaggataatatcaaacacgtcccgggaggc
ggcagtgtgcaaatagtctacaaaccagttgacctgagcaaggtgacctccaagtgtggc
tcattaggcaacatccatcataaaccaggaggtggccaggtggaagtaaaatctgagaag
cttgacttcaaggacagagtccagtcgaagattgggtccctggacaatatcacccacgtc
cctggcggaggaaataaaaagattgaaacccacaagctgaccttccgcgagaacgccaaa
gccaagacagaccacggggcggagatcgtgtacaagtcgccagtggtgtctggggacacg
tctccacggcatctcagcaatgtctcctccaccggcagcatcgacatggtagactcgccc
cagctcgccacgctagctgacgaggtgtctgcctccctggccaagcagggtttgtga

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