2ANQ: Crystal Structure of E.coli DHFR in complex with NADPH and the inhibitor compound 10a

PDB ID: 2ANQDownload
MMDB ID: 40247
PDB Deposition Date: 2005/8/11
Updated in MMDB: 2013/11
Experimental Method:
x-ray diffraction
Resolution: 2.13  Å
Source Organism:
Similar Structures:
Biological Unit for 2ANQ: monomeric; determined by author
Molecular Components in 2ANQ
Label Count Molecule
Protein (1 molecule)
1
Dihydrofolate Reductase
(Gene symbol: folA)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
2
MANGANESE (II) IONMANGANESE (II) ION
2
1
NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
3
1
(2,5-dimethylbenzene-1,4-diyl)dimethanediyl bis(N-carbamimidoylcarbamimidothioate)(2,5-dimethylbenzene-1,4-diyl)dimethanediyl bis(N-carbamimidoylcarbamimidothioate)
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303