4LUE: Crystal Structure of HCK in complex with 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (resulting from displacement of SKF86002)

PDB ID: 4LUEDownload
MMDB ID: 117490
PDB Deposition Date: 2013/7/25
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 3.04  Å
Source Organism:
Similar Structures:
Biological Unit for 4LUE: monomeric; determined by author and by software (PISA)
Molecular Components in 4LUE
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase HCK
(Gene symbol: HCK)
Molecule annotation
Chemicals and Non-standard biopolymers (6 molecules)
1
2
CALCIUM IONCALCIUM ION
2
1
7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
3
1
CHLORIDE IONCHLORIDE ION
4
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303