1MZC: Co-Crystal Structure Of Human Farnesyltransferase With Farnesyldiphosphate and Inhibitor Compound 33a

PDB ID: 1MZCDownload
MMDB ID: 23419
PDB Deposition Date: 2002/10/7
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2  Å
Source Organism:
Similar Structures:
Biological Unit for 1MZC: dimeric; determined by author and by software (PISA)
Molecular Components in 1MZC
Label Count Molecule
Proteins (2 molecules)
1
Protein Farnesyltransferase Alpha Subunit
(Gene symbol: FNTA)
Molecule annotation
1
Protein Farnesyltransferase Beta Subunit
(Gene symbol: FNTB)
Molecule annotation
Chemicals and Non-standard biopolymers (5 molecules)
1
1
alpha-D-glucopyranosealpha-D-glucopyranose
2
1
beta-D-fructofuranosebeta-D-fructofuranose
3
1
ZINC IONZINC ION
4
1
FARNESYL DIPHOSPHATEFARNESYL DIPHOSPHATE
5
1
2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE2-[3-(3-ETHYL-1-METHYL-2-OXO-AZEPAN-3-YL)-PHENOXY]-4-[1-AMINO-1-(1-METHYL-1H-IMIDIZOL-5-YL)-ETHYL]-BENZONITRILE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303