4H76: Crystal structure of the catalytic domain of Human MMP12 in complex with a broad spectrum hydroxamate inhibitor

PDB ID: 4H76Download
MMDB ID: 109388
PDB Deposition Date: 2012/9/20
Updated in MMDB: 2014/10
Experimental Method:
x-ray diffraction
Resolution: 1.5  Å
Source Organism:
Similar Structures:
Biological Unit for 4H76: monomeric; determined by author and by software (PISA)
Molecular Components in 4H76
Label Count Molecule
Protein (1 molecule)
1
Macrophage Metalloelastase
(Gene symbol: MMP12)
Molecule annotation
Chemicals and Non-standard biopolymers (13 molecules)
1
2
ZINC IONZINC ION
2
3
CALCIUM IONCALCIUM ION
3
1
N-2-(biphenyl-4-ylsulfonyl)-N-2-(isopropyloxy)-acetohydroxamic acidN-2-(biphenyl-4-ylsulfonyl)-N-2-(isopropyloxy)-acetohydroxamic acid
4
3
S-1,2-PROPANEDIOLS-1,2-PROPANEDIOL
5
3
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
6
1
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303