2GU8: Discovery Of 2-pyrimidyl-5-amidothiophenes As Novel And Potent Inhibitors For Akt: Synthesis And Sar Studies

PDB ID: 2GU8Download
MMDB ID: 45462
PDB Deposition Date: 2006/4/28
Updated in MMDB: 2007/10
Experimental Method:
x-ray diffraction
Resolution: 2.2  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 2GU8: dimeric; determined by author and by software (PISA)
Molecular Components in 2GU8
Label Count Molecule
Proteins (2 molecules)
1
Camp-dependent Protein Kinase, Alpha-catalytic Subunit
Molecule annotation
1
Inhibitor of Camp-dependent Protein Kinase
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[(1s)-2-Amino-1-(2,4-Dichlorobenzyl)ethyl]-5-[2-(Methylamino)pyrimidin-4-Yl]thiophene-2-CarboxamideNovartis 273796
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303