2Q1L: Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors

PDB ID: 2Q1LDownload
MMDB ID: 47519
PDB Deposition Date: 2007/5/24
Updated in MMDB: 2007/11
Experimental Method:
x-ray diffraction
Resolution: 2.05  Å
Source Organism:
Similar Structures:
Biological Unit for 2Q1L: tetrameric; determined by author and by software (PISA)
Molecular Components in 2Q1L
Label Count Molecule
Proteins (4 molecules)
4
3-hydroxy-3-methylglutaryl-coenzyme a Reductase
(Gene symbol: HMGCR)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
4
(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID(3R,5R)-7-[5-(ANILINOCARBONYL)-3,4-BIS(4-FLUOROPHENYL)-1-ISOPROPYL-1H-PYRROL-2-YL]-3,5-DIHYDROXYHEPTANOIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303