2UUE: REPLACE: A strategy for Iterative Design of Cyclin Binding Groove Inhibitors

PDB ID: 2UUEDownload
MMDB ID: 45391
PDB Deposition Date: 2007/3/2
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.06  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 2UUE: trimeric; determined by author and by software (PISA)
Molecular Components in 2UUE
Label Count Molecule
Proteins (3 molecules)
1
Cell Division Protein Kinase 2
Molecule annotation
1
Cyclin A2
Molecule annotation
1
Gvc-tetrapeptide Inhibitor
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE4-METHYL-5-{(2E)-2-[(4-MORPHOLIN-4-YLPHENYL)IMINO]-2,5-DIHYDROPYRIMIDIN-4-YL}-1,3-THIAZOL-2-AMINE
2
1
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303