3JQB: Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor (NADP+) and inhibitor 2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one (DX6)

PDB ID: 3JQBDownload
MMDB ID: 78612
PDB Deposition Date: 2009/9/6
Updated in MMDB: 2009/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 3JQB: tetrameric; determined by author and by software (PISA)
Molecular Components in 3JQB
Label Count Molecule
Proteins (4 molecules)
3
Pteridine Reductase 1
Molecule annotation
1
Pteridine Reductase 1
Molecule annotation
Chemicals and Non-standard biopolymers (8 molecules)
1
4
NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATENADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
2
3
2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one2-amino-5-(2-phenylethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one
3
1
2,3-DIHYDROXY-1,4-DITHIOBUTANE2,3-DIHYDROXY-1,4-DITHIOBUTANE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303