3P8N: Crystal structure of HCV NS3/NS4A protease complexed with BI 201335

PDB ID: 3P8NDownload
MMDB ID: 88238
PDB Deposition Date: 2010/10/14
Updated in MMDB: 2018/11
Experimental Method:
x-ray diffraction
Resolution: 1.9  Å
Source Organism:
synthetic construct▼
Similar Structures:
Biological Unit for 3P8N: dimeric; determined by author and by software (PISA)
Molecular Components in 3P8N
Label Count Molecule
Proteins (2 molecules)
1
HCV Serine Protease NS3
Molecule annotation
1
HCV Non-structural Protein 4A
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
SODIUM IONSODIUM ION
2
1
N-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(8-bromo-7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-L-prolinamideN-[(cyclopentyloxy)carbonyl]-3-methyl-L-valyl-(4R)-4-[(8-bromo-7-methoxy-2-{2-[(2-methylpropanoyl)amino]-1,3-thiazol-4-yl}quinolin-4-yl)oxy]-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-L-prolinamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303