4AFJ: 5-aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

PDB ID: 4AFJDownload
MMDB ID: 97684
PDB Deposition Date: 2012/1/19
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 4AFJ: dimeric; determined by author and by software (PISA)
Molecular Components in 4AFJ
Label Count Molecule
Proteins (2 molecules)
1
Glycogen Synthase Kinase-3 Beta
(Gene symbol: GSK3B)
Molecule annotation
1
Proto-oncogene Frat1
(Gene symbol: FRAT1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
3
SULFATE IONSULFATE ION
2
3
GLYCEROLGLYCEROL
3
1
5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE5-(4-METHOXYPHENYL)-N-(PYRIDIN-4-YLMETHYL)-1,3-OXAZOLE-4-CARBOXAMIDE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303