3C27: Cyanofluorophenylacetamides As Orally Efficacious Thrombin Inhibitors

PDB ID: 3C27Download
MMDB ID: 69661
PDB Deposition Date: 2008/1/24
Updated in MMDB: 2012/10
Experimental Method:
x-ray diffraction
Resolution: 2.18  Å
Source Organism:
Homo sapiens▼
Similar Structures:
Biological Unit for 3C27: trimeric; determined by author and by software (PISA)
Molecular Components in 3C27
Label Count Molecule
Proteins (3 molecules)
1
Thrombin Light Chain
Molecule annotation
1
Thrombin Heavy Chain
Molecule annotation
1
Hirudin-3a
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
N-[2-(Carbamimidamidooxy)ethyl]-2-{6-Cyano-3-[(2,2-Difluoro-2-Pyridin-2-Ylethyl)amino]-2-Fluorophenyl}acetamideN-[2-(Carbamimidamidooxy)ethyl]-2-{6-Cyano-3-[(2,2-Difluoro-2-Pyridin-2-Ylethyl)amino]-2-Fluorophenyl}acetamide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303