4EZK: Potent and Selective Inhibitors of PI3K-delta: Obtaining Isoform Selectivity from the Affinity Pocket and Tryptophan Shelf

PDB ID: 4EZKDownload
MMDB ID: 109179
PDB Deposition Date: 2012/5/2
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 2.803  Å
Source Organism:
Similar Structures:
Biological Unit for 4EZK: monomeric; determined by author and by software (PISA)
Molecular Components in 4EZK
Label Count Molecule
Protein (1 molecule)
1
Phosphatidylinositol 4,5-bisphosphate 3-kinase Catalytic Subunit Gamma Isoform
(Gene symbol: PIK3CG)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol2-(1-{[2-(2H-indazol-4-yl)-4-(morpholin-4-yl)pyrido[3,2-d]pyrimidin-6-yl]methyl}piperidin-4-yl)propan-2-ol
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303