4AOJ: Human TrkA in complex with the inhibitor AZ-23

PDB ID: 4AOJDownload
MMDB ID: 101964
PDB Deposition Date: 2012/3/28
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.75  Å
Source Organism:
Similar Structures:
Biological Unit for 4AOJ: dodecameric; determined by author and by software (PISA)
Molecular Components in 4AOJ
Label Count Molecule
Proteins (12 molecules)
12
High Affinity Nerve Growth Factor Receptor
(Gene symbol: NTRK1)
Molecule annotation
Chemicals and Non-standard biopolymers (36 molecules)
1
12
5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine5-chloranyl-N2-[(1S)-1-(5-fluoranylpyridin-2-yl)ethyl]-N4-(3-propan-2-yloxy-1H-pyrazol-5-yl)pyrimidine-2,4-diamine
2
24
ZINC IONZINC ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303