4F09: Discovery and Optimization of C-2 Methyl Imidazo-pyrrolopyridines as Potent and Orally Bioavailable JAK1 Inhibitors with Selectivity over JAK2

PDB ID: 4F09Download
MMDB ID: 101065
PDB Deposition Date: 2012/5/3
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.4  Å
Source Organism:
Similar Structures:
Biological Unit for 4F09: monomeric; determined by author and by software (PISA)
Molecular Components in 4F09
Label Count Molecule
Protein (1 molecule)
1
Tyrosine-protein Kinase Jak2
(Gene symbol: JAK2)
Molecule annotation
Chemical and Non-standard biopolymers (1 molecule)
1
1
2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine2-methyl-1-(piperidin-4-yl)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303