3FC2: PLK1 in complex with BI6727

PDB ID: 3FC2Download
MMDB ID: 72610
PDB Deposition Date: 2008/11/21
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 2.45  Å
Source Organism:
Similar Structures:
Biological Unit for 3FC2: dimeric; determined by author and by software (PISA)
Molecular Components in 3FC2
Label Count Molecule
Proteins (2 molecules)
2
Serine/threonine-protein Kinase Plk1
(Gene symbol: PLK1)
Molecule annotation
Chemicals and Non-standard biopolymers (20 molecules)
1
2
N-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamideN-{trans-4-[4-(cyclopropylmethyl)piperazin-1-yl]cyclohexyl}-4-{[(7R)-7-ethyl-5-methyl-8-(1-methylethyl)-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxybenzamide
2
8
1,2-ETHANEDIOL1,2-ETHANEDIOL
3
4
ACETATE IONACETATE ION
4
2
DI(HYDROXYETHYL)ETHERDI(HYDROXYETHYL)ETHER
5
2
ZINC IONZINC ION
6
2
GLYCEROLGLYCEROL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303