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3V04:
Discovery of Novel Allosteric MEK Inhibitors Possessing Classical and Non-classical Bidentate Ser212 Interactions
PDB ID:
3V04
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MMDB ID:
99369
PDB Deposition Date:
2011/12/7
Updated in MMDB:
2023/09
Experimental Method:
x-ray diffraction
Resolution:
2.7 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 3V04: monomeric; determined by author and by software (PISA)
Molecular Components in 3V04
Label
Count
Molecule
Protein (1 molecule)
A
1
Dual Specificity Mitogen-activated Protein Kinase Kinase 1
(Gene symbol:
MAP2K1
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
4-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1H-indazole-5-carboxamide
2
1
ADENOSINE-5'-TRIPHOSPHATE
3
1
MAGNESIUM ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303