4NK9: Crystal structure of human fibroblast growth factor receptor 1 kinase domain in complex with pyrazolaminopyrimidine 1

PDB ID: 4NK9Download
MMDB ID: 116114
PDB Deposition Date: 2013/11/12
Updated in MMDB: 2013/12
Experimental Method:
x-ray diffraction
Resolution: 2.57  Å
Source Organism:
Similar Structures:
Biological Unit for 4NK9: dimeric; determined by author
Molecular Components in 4NK9
Label Count Molecule
Proteins (2 molecules)
2
Fibroblast Growth Factor Receptor 1
(Gene symbol: FGFR1)
Molecule annotation
Chemicals and Non-standard biopolymers (9 molecules)
1
4
1,2-ETHANEDIOL1,2-ETHANEDIOL
2
3
SULFATE IONSULFATE ION
3
2
N~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamineN~4~-{5-[2-(3,5-dimethoxyphenyl)ethyl]-1H-pyrazol-3-yl}-N~2~-[(3-methyl-1,2-oxazol-5-yl)methyl]pyrimidine-2,4-diamine
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303