4I4F: Structure of Focal Adhesion Kinase catalytic domain in complex with an allosteric binding pyrazolobenzothiazine compound

PDB ID: 4I4FDownload
MMDB ID: 107355
PDB Deposition Date: 2012/11/27
Updated in MMDB: 2023/09
Experimental Method:
x-ray diffraction
Resolution: 1.75  Å
Source Organism:
Similar Structures:
Biological Unit for 4I4F: monomeric; determined by author and by software (PISA)
Molecular Components in 4I4F
Label Count Molecule
Protein (1 molecule)
1
Focal Adhesion Kinase 1
(Gene symbol: PTK2)
Molecule annotation
Chemicals and Non-standard biopolymers (2 molecules)
1
1
ISOPROPYL ALCOHOLISOPROPYL ALCOHOL
2
1
N-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxideN-(4-tert-butylbenzyl)-1,5-dimethyl-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-amine 4,4-dioxide
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303