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4O75:
Crystal structure of the first bromodomain of human BRD4 in complex with FOSTAMATINIB
PDB ID:
4O75
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MMDB ID:
118087
PDB Deposition Date:
2013/12/24
Updated in MMDB:
2023/09
Experimental Method:
x-ray diffraction
Resolution:
1.55 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
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Biological Unit for 4O75: monomeric; determined by author and by software (PISA)
Molecular Components in 4O75
Label
Count
Molecule
Protein (1 molecule)
A
1
Bromodomain-containing Protein 4
(Gene symbol:
BRD4
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
[6-({5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}amino)-2,2-dimethyl-3-oxo-2,3-dihydro-4H-pyrido[3,2-b][1,4]oxazin-4-yl]methyl dihydrogen phosphate
2
2
1,2-ETHANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303