4HXX: Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

PDB ID: 4HXXDownload
MMDB ID: 108868
PDB Deposition Date: 2012/11/12
Updated in MMDB: 2019/11
Experimental Method:
x-ray diffraction
Resolution: 2.09  Å
Source Organism:
Similar Structures:
Biological Unit for 4HXX: monomeric; determined by author and by software (PISA)
Molecular Components in 4HXX
Label Count Molecule
Protein (1 molecule)
1
Methionine Aminopeptidase 1
(Gene symbol: METAP1)
Molecule annotation
Chemicals and Non-standard biopolymers (7 molecules)
1
3
COBALT (II) IONCOBALT (II) ION
2
1
POTASSIUM IONPOTASSIUM ION
3
1
(1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine(1R)-N~2~-[5-chloro-2-(5-chloropyridin-2-yl)-6-methylpyrimidin-4-yl]-1-phenyl-N~1~-(4-phenylbutyl)ethane-1,2-diamine
4
2
SULFATE IONSULFATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303