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4J52:
Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
PDB ID:
4J52
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MMDB ID:
110546
PDB Deposition Date:
2013/2/7
Updated in MMDB:
2017/11
Experimental Method:
x-ray diffraction
Resolution:
2.3 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4J52: monomeric; determined by author
Molecular Components in 4J52
Label
Count
Molecule
Protein (1 molecule)
A
1
Serine/threonine-protein Kinase Plk1
(Gene symbol:
PLK1
)
Chemicals and Non-standard biopolymers (3 molecules)
1
1
4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide
2
1
ZINC ION
3
1
ACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303