NCBI
National Center for
Biotechnology Information
Search
4DST:
Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity
PDB ID:
4DST
Download
MMDB ID:
98578
PDB Deposition Date:
2012/2/19
Updated in MMDB:
2012/06
Experimental Method:
x-ray diffraction
Resolution:
2.3 Å
Source Organism:
Homo sapiens
Similar Structures:
VAST+
Download sequence data
Biological Unit for 4DST: monomeric; determined by author and by software (PISA)
Molecular Components in 4DST
Label
Count
Molecule
Protein (1 molecule)
A
1
Gtpase Kras, Isoform 2B
(Gene symbol:
KRAS
)
Chemicals and Non-standard biopolymers (8 molecules)
1
1
2-(4,6-dichloro-2-methyl-1H-indol-3-yl)ethanamine
2
1
PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
3
2
MAGNESIUM ION
4
1
GLYCEROL
5
1
1,2-ETHANEDIOL
6
1
DIMETHYL SULFOXIDE
7
1
ACETATE ION
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH.
"
MMDB and VAST+: tracking structural similarities between macromolecular complexes.
Nucleic Acids Res. 2014 Jan; 42(Database issue)
:D297-303