3ZO2: The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors

PDB ID: 3ZO2Download
MMDB ID: 160652
PDB Deposition Date: 2013/2/20
Updated in MMDB: 2023/12
Experimental Method:
x-ray diffraction
Resolution: 1.98  Å
Source Organism:
Similar Structures:
Biological Unit for 3ZO2: dimeric; determined by author and by software (PISA)
Molecular Components in 3ZO2
Label Count Molecule
Proteins (2 molecules)
1
Camp-dependent Protein Kinase Catalytic Subunit Alpha
(Gene symbol: PRKACA)
Molecule annotation
1
Camp-dependent Protein Kinase Inhibitor Alpha
(Gene symbol: Pkia)
Molecule annotation
Chemicals and Non-standard biopolymers (4 molecules)
1
1
6-(2,9-Diazaspiro[5.5]undecan-9-yl)-9H-purine6-(2,9-Diazaspiro[5.5]undecan-9-yl)-9H-purine
2
2
GLYCEROLGLYCEROL
3
1
(4S)-2-METHYL-2,4-PENTANEDIOL(4S)-2-METHYL-2,4-PENTANEDIOL
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303