4DSU: Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

PDB ID: 4DSUDownload
MMDB ID: 98579
PDB Deposition Date: 2012/2/19
Updated in MMDB: 2012/06
Experimental Method:
x-ray diffraction
Resolution: 1.7  Å
Source Organism:
Similar Structures:
Biological Unit for 4DSU: monomeric; determined by author and by software (PISA)
Molecular Components in 4DSU
Label Count Molecule
Protein (1 molecule)
1
Gtpase Kras, Isoform 2B
(Gene symbol: KRAS)
Molecule annotation
Chemicals and Non-standard biopolymers (3 molecules)
1
1
GUANOSINE-5'-DIPHOSPHATEGUANOSINE-5'-DIPHOSPHATE
2
1
MAGNESIUM IONMAGNESIUM ION
3
1
BENZIMIDAZOLEBENZIMIDAZOLE
* Click molecule labels to explore molecular sequence information.
Citing MMDB
Madej T, Lanczycki CJ, Zhang D, Thiessen PA, Geer RC, Marchler-Bauer A, Bryant SH. " MMDB and VAST+: tracking structural similarities between macromolecular complexes. Nucleic Acids Res. 2014 Jan; 42(Database issue):D297-303