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11947Structure-based Design and Synthesis of Lipophilic 2,4- Diamino-6-substituted Quinazolines and Their Evaluation as Inhibitors of Dihydrofolate Reductase and Potential Antitumor Agents
752Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed With Folate and 5-deazofolate
55930Methotrexate-resistant Variants of Human Dihydrofolate Reductase With Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
55931Methotrexate-resistant Variants of Human Dihydrofolate Reductase With Substitution of Leucine 22: Kinetics, Crystallography and Potential as Selectable Markers
55965Crystal Structure of Human Dihydrofolate Reductase Complexed With Folate
56332Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine
56333Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine
56334Comparison of Ternary Crystal Complexes of Human Dihydrofolate Reductase With Nadph and a Classical Antitumor Furopyrimdine
20168Human Dihydrofolate Reductase Complexed With Nadph and 6- ([5-quinolylamino]methyl)-2,4-diamino-5-methylpyrido[2,3- D]pyrimidine (Sri-9439), a Lipophilic Antifolate
20169Human Dihydrofolate Reductase Complexed With Nadph and (Z)- 6-(2-[2,5-dimethoxyphenyl]ethen-1-yl)-2,4-diamino-5- Methylpyrido[2,3-d]pyrimidine (Sri-9662), a Lipophilic Antifolate
22352Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex With Human Dihydrofolate Reductase
22353Analysis of Two Polymorphic Forms of a Pyrido[2,3- D]pyrimidine N9-c10 Reverse-bridge Antifolate Binary Complex With Human Dihydrofolate Reductase
57029Human Dihydrofolate Reductase, Monoclinic (P21) Crystal Form
57030Human Dihydrofolate Reductase, Orthorhombic (P21 21 21) Crystal Form
25683Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase
25684Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase
25685Analysis of Three Crystal Structure Determinations of a 5- Methyl-6-n-methylanilino Pyridopyrimidine Antifolate Complex With Human Dihydrofolate Reductase
26995Structure Determination of Tetrahydroquinazoline Antifolates in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
26996Structure Determination of Tetrahydroquinazoline Antifolates in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
26997Structure Determination of Tetrahydroquinazoline Antifoaltes in Complex With Human and Pneumocystis Carinii Dihydrofolate Reductase: Correlations of Enzyme Selectivity and Stereochemistry
31293Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrofolate Reductase
31294Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrofolate Reductase Ternary Crystal Complexes With Methotrexate and Nadph
31295Understanding the Role of Leu22 Variants in Methotrexate Resistance: Comparison of Wild-type and Leu22arg Variant Mouse and Human Dihydrfolate Reductase Ternary Crystal Complexes With Methotrexate and Nadph
35994Solution Structure of Human Dihydrofolate Reductase Complexed With Trimethoprim and Nadph, 25 Structures
45877Human Dihydrofolate Reductase Complexed With Nadph and 2,4- Diamino-5-(1-o-carboranylmethyl)-6-methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
45878Human Dihydrofolate Reductase Complexed With Nadph and 2,4- Diamino-5-((7,8-dicarbaundecaboran-7-yl)methyl)-6- Methylpyrimidine, a Novel Boron Containing, Nonclassical Antifolate
2643Crystal Structures of Recombinant Human Dihydrofolate Reductase Complexed With Folate and 5-deazofolate
43321NEW Insights Into Dhfr Interactions: Analysis of Pneumocystis Carinii and Mouse Dhfr Complexes With Nadph and Two Highly Potent Trimethoprim Derivatives
78125Human Dihydrofolate Reductase Complexed With Nadph and Trimethoprim
78126Human Dihydrofolate Reductase Complexed With Nadph and a Lipophilic Antifolate Selective for Mycobacterium Avium Dhfr, 6-((2,5-diethoxyphenyl)aminomethyl)-2,4-diamino-5- Methylpyrido(2,3-d)pyrimidine (Sri-8686)
78127Human Dihydrofolate Reductase Complexed With Nadph and Folate
66908Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase With Nadph and a Ternary Complex Wtih the Potent and Selective Inhibitor 2,4-diamino-6-(2'-hydroxydibenz[b,f]azepin-5-yl) Methylpteridine
66909Structural Analysis of a Holo Enzyme Complex of Mouse Dihydrofolate Reductase With Nadph and a Ternary Complex With the Potent and Selective Inhibitor 2.4-diamino-6-(-2'-hydroxydibenz[b,f]azepin-5- Yl)methylpteridine
72890Crystal Structure of a Methotrexate-resistant Mutant of Human Dihydrofolate Reductase
76069Correlations of Human Dihydrofolate Reductase With Structural Data for Human Active Site Mutant Enzyme Complexes
76070Human Dihydrofolate Reductase Structural Data With Active Site Mutant Enzyme Complexes
76071Structural Data for Human Active Site Mutant Enzyme Complexes
76079Correlations of Inhibitor Kinetics for Pneumocystis Jirovecii and Human Dihydrofolate Reductase With Structural Data for Human Active Site Mutant Enzyme Complexes
76848Design, Synthesis, and X-ray Crystal Structure of Classical and Nonclassical 2-amino-4-oxo-5-substituted-6-thieno[2,3- D]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors and as Potential Antitumor Agenst
76849Human Dihydrofolate Reductase Q35kn64f Double Mutant Inhibitor Complex
76850Human Dihydrofolate Reductase Inhibitor Complex
77015Human Dihydrofolate Reductase Q35k Mutant Inhibitor Complex
77812Human Dhfr With Z-isomer in Orthorhombic Lattice
77391Alternate Binding Modes Observed for the E- and Z-isomers of 2,4- Diaminofuro[2,3d]pyrimidines as Ternary Complexes With Nadph and Mouse Dihydrofolate Reductase
77392Alternate Binding Modes Observed for the E- and Z-isomers of 2,4- Diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Mouse Dihydrofolate Reductase
87683Structural, Computational and Kinetic Data for Antifolate Interactions Against Pneumocystis Jirovecii, Pneumocystis Carinii and Human Dihydrofolate Reductase and Their Active Site Mutants
90788Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
90789Design, Synthesis, Biological Evaluation and X-ray Crystal Structure of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
86622Perferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
86623Perferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
86624Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E-and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2m,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
86625Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
87335Preferential Selection of Isomer Binding From Chiral Mixtures: Alternate Binding Modes Observed for the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro-2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
87336Preferential Selection of Isomer Binding From Chiral Mixtures: Alernate Binding Modes Observed FRO the E- and Z-isomers of a Series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as Ternary Complexes With Nadph and Human Dihydrofolate Reductase
87614Structural Analysis of Pneumocystis Carinii and Human Dhfr Complexes With Nadph and a Series of Five 5-(omega-carboxy(alkyloxy(pyrido[2,3- D]pyrimidine Derivatives