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MMDB Description
73437Hiv-1 Protease in Complex With Sdz283-910
8033G48h Mutant of Hiv-1 Protease in Complex With a Peptidic Inhibitor U-89360e
158Hydroxyethylene Isostere Inhibitors of Human Immunodeficiency Virus-1 Protease: Structure-activity Analysis Using Enzyme Kinetics, X-ray Crystallography, and Infected T-cell Assays
6331Hiv-1 Protease in Complex With the Cyclic Sulfamide Inhibitor Aha006
6457Hiv-1 Protease in Complex With the Cyclic Urea Inhibitor Aha001
7498Active-site Mobility in Human Immunodeficiency Virus Type 1 Protease as Demonstrated by Crystal Structure of A28s Mutant
14954Alternate Binding Site for the P1-p3 Group of a Class of Potent Hiv-1 Protease Inhibitors as a Result of Concerted Structural Change in 80's Loop
19717Hiv-1 Protease in Complex With the Inhibitor Bea435
19718Hiv-1 Protease in Complex With the Inhibitor Bea425
19719Hiv-1 Protease in Complex With the Inhibitor Msl370
4447Hiv-1 Protease in Complex With a Difluoroketone Containing Inhibitor A79285
19722Hiv-1 Protease in Complex With the Inhibitor Bea322
19723Hiv-1 Protease in Complex With the Inhibitor Bea369
19724Hiv-1 Protease in Complex With the Inhibitor Bea388
19725Hiv-1 Protease in Complex With the Inhibitor Bea403
19726Hiv-1 Protease in Complex With the Inhibitor Bea409
19727Hiv-1 Protease in Complex With the Inhibitor Bea428
19728Hiv-1 Protease in Complex With the Inhibitor Msa367
73608Crystal Structure of the Complex of Hiv-1 Protease With a Peptidomimetic Inhibitor
16449Hiv-1 Protease With Cyclic Sulfamide Inhibitor, Aha047
16387Crystal Structure of Hiv-1 Protease in Complex With Inhibitor, Aha024
5732Hiv-1 Protease Mutant With VAL 82 Replaced by ASP (V82d) Complexed With U89360e (Inhibitor)
5733Hiv-1 Protease Mutant With VAL 82 Replaced by ASN (V82n) Complexed With U89360e (Inhibitor)
5734Hiv-1 Protease (Wild Type) Complexed With U89360e (Inhibitor)
3498a Check on Rational Drug Design. Crystal Structure of a Complex of Hiv-1 Protease With a Novel Gamma-turn Mimetic
76639The Crystal Structures at 2.2 Angstroms Resolution of Hydroxyethylene-based Inhibitors Bound to Human Immunodeficiency Virus Type 1 Protease Show That the Inhibitors ARE Present in Two Distinct Orientations
73641The Crystal Structures at 2.2 Angstroms Resolution of Hydroxyethylene-based Inhibitors Bound to Human Immunodeficiency Virus Type 1 Protease Show That the Inhibitors ARE Present in Two Distinct Orientations
56338The Three-dimensional Structure of the Aspartyl Protease From the Hiv-1 Isolate BRU
3495Comparative Analysis of the X-ray Structures of Hiv-1 and Hiv-2 Proteases in Complex With CGP 53820, a Novel Pseudosymmetric Inhibitor
73646Crystal Structure of a Complex of Hiv-1 Protease With a Dihydroethylene-containing Inhibitor: Comparisons With Molecular Modeling
1233Inhibition of Human Immunodeficiency Virus-1 Protease by a C2- Symmetric Phosphinate Synthesis and Crystallographic Analysis
1237Rational Design, Synthesis and Crystallographic Analysis of a Hydroxyethylene-based Hiv-1 Protease Inhibitor Containing a Heterocyclic P1'-p2' Amide Bond Isostere
1239Crystal Structure of Hiv-1 Protease in Complex With Vx-478, a Potent and Orally Bioavailable Inhibitor of the Enzyme
4428Hiv-1 Protease Complexed With the Inhibitor Kni-272
4292Crystal Structure at 1.9 Angstroms Resolution of Human Immunodeficiency Virus (Hiv) II Protease Complexed With L- 735,524, an Orally Bioavailable Inhibitor of the HIV Proteases
1260X-ray Crystallographic Studies of a Series of Penicillin- Derived Asymmetric Inhibitors of Hiv-1 Protease
1261X-ray Crystallographic Studies of a Series of Penicillin- Derived Asymmetric Inhibitors of Hiv-1 Protease
1262X-ray Crystallographic Studies of a Series of Penicillin- Derived Asymmetric Inhibitors of Hiv-1 Protease
1281Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-based Diol Inhibitors of Hiv-1 Protease
1282Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-based Diol Inhibitors of Hiv-1 Protease
1283Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-based Diol Inhibitors of Hiv-1 Protease
1284Influence of Stereochemistry on Activity and Binding Modes for C2 Symmetry-based Diol Inhibitors of Hiv-1 Protease
1289Structural Basis of Drug Resistance for the V82a Mutant of Hiv-1 Protease: Backbone Flexibility and Subsite Repacking
49549Hiv-1 Proteinase Complexed With RO 31-8959
7007Hiv-1 Protease Dimer Complexed With A-84538
49668Crystal Structure of Hiv-1 Protease Complexed With a Hydroxyethylamine Peptidomimetic Inhibitor
21361Inhibitor of HIV Protease With Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
21362Inhibitor of HIV Protease With Unusual Binding Mode Potently Inhibiting Multi-resistant Protease Mutants
50197Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71v, V82t, I84v) With an Ethylenamine Peptidomimetic Inhibitor Boc-phe-psi[ch2ch2nh]-phe-glu-phe-nh2
50201Hiv-1 Protease in Complex With an Ethyleneamine Inhibitor
21013Crystal Structure of Hiv-1 Protease Complexed With Lopinavir
504621.03 a Structure of Hiv-1 Protease: Inhibitor Binding Inside and Outside the Active Site
26006Crystal Structure of Hiv-1 Protease-hup
21903Crystal Structure of Hiv-1 Protease Complexed With Ldc271
21904Crystal Structure of HIV Protease Complexed With Lgz479
50612Native Hiv-1 Proteinase
50613Hiv-1 Proteinase Mutant A71t, V82a
9068Viracept (R) (Nelfinavir Mesylate, Ag1343): a Potent Orally Bioavailable Inhibitor of Hiv-1 Protease
4836Hiv-1 Protease Dimer Complexed With A-98881
32717Crystal Structure of the Complex of Resistant Strain of Hiv- 1 Protease(v82a Mutant) With Ritonavir
2155An Orally-bioavailable Hiv-1 Protease Inhibitor Containing an Imidazole-derived Peptide Bond Replacement. Crystallographic and Pharmacokinetic Analysis
34058Crystal Structure of Hiv-1 Protease Complexed With a Product of Autoproteolysis
29418Crystal Structure of HIV Protease Complexed With Arylsulfonamide Azacyclic Urea
74346Crystal Structure of a Hiv-1 Protease in Complex With Peptidomimetic Inhibitor Ki2-phe-glu-glu-nh2
57578Hiv-1 Protease Complex With U095438 [3-[1-(4-bromophenyl) Isobutyl]-4- Hydroxycoumarin
9368Hiv-1 Protease Complexed With the Inhibitor Hoebay 793 Hexagonal Form
9073Hiv-1 Protease Complexed With the Inhibitor Hoebay 793 Orthorhombic Form
31015Hiv-1 Protease in Complex With Fluoro Substituted Diol- Based C2-symmetric Inhibitor
31016Hiv-1 Protease in Complex With Fluoro Substituted Diol- Based C2-symmetric Inhibitor
34484Hiv-1 Protease in Complex With Fluoro Substituted Diol- Based C2-symmetric Inhibitor
30102Hiv-1 Protease in Complex With Fluoro Substituted Diol- Based C2-symmetric Inhibitor
30471Hiv-1 Protease in Complex With Asymmetric Inhibitor, Bea568
30472Hiv-1 Protease in Complex With Symmetric Inhibitor, Bea450
33692Hiv-1 Protease in Complex With Pyrrolidinmethanamine
33693Hiv-1 Protease in Complex With Amidhyroxysulfone
32957HIV Protease With Oximinoarylsulfonamide Bound
52209Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71v, V82t, I84v) With a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe-psi[r-ch(oh)ch2nh]-phe-glu-phe-nh2
74482Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71v, V82t, I84v) With a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe-psi[s-ch(oh)ch2nh]-phe-glu-phe-nh2
74485Crystal Structure of a Complex of Mutant Hiv-1 Protease (A71v, V82t, I84v) With a Hydroxyethylamine Peptidomimetic Inhibitor
33905HIV Protease With Inhibitor Ab-2
33190HIV Protease With Scripps Ab-3 Inhibitor
52289Crystal Structure of the Complex of Mutant Hiv-1 Protease (A71v, V82t, I84v) With a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe-psi[r-ch(oh)ch2nh]-phe-glu-phe-nh2
74491Crystal Structure of Complex of a Hydroxyethylamine Inhibitor With Hiv-1 Protease at 2.0a Resolution
74492Crystal Structure of Wild Type Hiv-1 Protease (Bru Isolate) With a Hydroxyethylamine Peptidomimetic Inhibitor Boc-phe- Psi[s-ch(oh)ch2nh]-phe-glu-phe-nh2
35165Synthesis and Activity of N-axyl Azacyclic Urea Hiv-1 Protease Inhibitors With High Potency Against Multiple Drug Resistant Viral Strains
40657Structure of Hiv-1 Protease Bound to Atazanavir
52537Hiv-1 Protease Nl4-3 in Complex With Inhibitor, Tl-3
52538Hiv-1 Protease Nl4-3 1X Mutant
36187Structure of Hiv1 Protease and Akc4p_133a Complex
36188Structure of Hiv1 Protease and Hh1_173_3a Complex
9577Hiv-1 Protease-inhibitor Complex
9578Hiv-1 Protease-inhibitor Complex
9579Hiv-1 Protease-inhibitor Complex
9580Hiv-1 Protease-inhibitor Complex
9581Hiv-1 Protease-inhibitor Complex
36732Hiv-1 Protease in Complex With Inhibitor Aha455
44310P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-state Mimicking Scaffold
44311P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-state Mimicking Scaffold
44312P1' Extended Hiv-1 Protease Inhibitors Encompassing a Tertiary Alcohol in the Transition-state Mimicking Scaffold
37730Wild Type HIV Protease Bound With Gw0385
43759Structural Analysis of Asymmetric Inhibitor Bound to the Hiv-1 Protease V82a Mutant
47125Structure of HIV Protease Nl4-3 in an Unliganded State
58047Three-dimensional Structure of Aspartyl Protease From Human Immunodeficiency Virus Hiv-1
60050Crystal Structure of WT Hiv-1 Protease With Gs-8373
58951Hiv-1 Protease With Tmc-126
58953Hiv-1 Protease WT With Gs-8374
43605Crystal Structure of Hiv-1 Protease (Q7k) in Complex With Atazanavir
43606Crystal Structure of Hiv-1 Protease (Q7k, I50v) in Complex With Tipranavir
43608Crystal Structure of Hiv-1 Protease (Q7k) in Complex With Tipranavir
43609Crystal Structure of Hiv-1 Protease (Q7k) in Complex With Lopinavir
45723Crystal Structure of the Subtype B Wild Type HIV Protease Complexed With Tl-3 Inhibitor
47218APO Wild-type HIV Protease in the Open Conformation
63765Hiv-1 Protease in Complex With a Pyrrolidine-based Inhibitor
63769Hiv-1 Protease in Complex With a Amino Decorated Pyrrolidine-based Inhibitor
63770Hiv-1 Protease in Complex With a Carbamoyl Decorated Pyrrolidine-based Inhibitor
62669Hiv-1 PR Mutant in Complex With Nelfinavir
65545The Influence of I47a Mutation on Reduced Susceptibility to the Protease Inhibitor Lopinavir
65553Crystal Structure of Hiv-1 Protease Complexed With Pl-100
63777Hiv-1 Protease in Complex With a Multiple Decorated Pyrrolidine-based Inhibitor
63778Hiv-1 Protease in Complex With a Iodo Decorated Pyrrolidine- Based Inhibitor
63779Hiv-1 Protease in Complex With a Chloro Decorated Pyrrolidine-based Inhibitor
66402I84v Hiv-1 Protease Mutant in Complex With a Carbamoyl Decorated Pyrrolidine-based Inhibitor
66403I50v Hiv-1 Protease Mutant in Complex With a Carbamoyl Decorated Pyrrolidine-based Inhibitor
66404I84v Hiv-1 Protease in Complex With a Amino Decorated Pyrrolidine-based Inhibitor
66548I50v Hiv-1 Protease in Complex With an Amino Decorated Pyrrolidine- Based Inhibitor
4714Hiv-1 Protease Complex With U100313 ([3-[[3-[cyclopropyl [4-hydroxy- 2oxo-6-[1-(phenylmethyl)propyl]-2h-pyran-3-yl] Methyl]phenyl]amino]- 3-oxo-propyl]carbamic Acid Tert-butyl Ester)
64505Two-carbon-elongated Hiv-1 Protease Inhibitors With a Tertiary-alcohol-containing Transition-state Mimic
64506Two-carbon-elongated Hiv-1 Protease Inhibitors With a Tertiary-alcohol-containing Transition-state Mimic
78684Hiv-1 Protease Inhibitors Containing a Tertiary Alcohol in the Transition-state Mimic With Improved Cell-based Antiviral Activity
69386Hiv-1 Protease in Complex With a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (Hexagonal Space Group)
66440I84v Hiv-1 Protease in Complex With a Pyrrolidine Diester
66441Hiv-1 Protease in Complex With a Isobutyl Decorated Oligoamine
66442Hiv-1 Protease in Complex With a Benzyl Decorated Oligoamine
68388Hiv-1 Protease in Complex With a Three Armed Pyrrolidine Derivative
70361Hiv-1 Protease in Complex With a Dimethylallyl Decorated Pyrrolidine Based Inhibitor (Orthorombic Space Group)
65416Crystal Structure of Hiv-1 Crf01_ae in Complex With the Substrate P1-p6
72913HIV Protease Inhibitors With Pseudo-symmetric Cores
72914HIV Protease, Pseudo-symmetric Inhibitors
72915HIV Protease, Pseudo-symmetric Inhibitors
80460Crystal Structure of Uncomplexed Hiv_1 Protease Subtype a
80269HIV Protease With Fragment 4D9 Bound
80273HIV Protease (Pr) With Inhibitor Tl-3 and Fragment HIT 4D9 by Soaking
80274HIV Protease (Pr) With Inhibitor Tl-3 Bound, and Dmsos in EXO Site
80275HIV Protease (Pr) Dimer With Inhibitor Tl-3 Bound and Fragment 1F1 in the Outsidetop of Flap
80276HIV Protease (Pr) Dimer With Inhibitor Tl-3 Bound and Fragment 2F4 in the Outside/top of Flap
84004Crystal Structure of Hiv-1 Crf01_ae Protease in Complex With Darunavir
84005Crystal Structure of a Nelfinavir Resistant Hiv-1 Crf01_ae Protease Variant (N88s) in Complex With the Protease Inhibitor Darunavir
83066HIV Protease Complexed With Compound 10B
58353X-ray Analysis of Hiv-1 Proteinase at 2.7 Angstroms Resolution Confirms Structural Homology Among Retroviral Enzymes
12235Structural Studies of HIV and FIV Proteases Complexed Withan Efficient Inhibitor of FIV PR
3200X-ray Crystal Structure of the HIV Protease Complex With L- 700,417, an Inhibitor With Pseudo C2 Symmetry
54778Crystallographic Analysis of a Complex Between Human Immunodeficiency Virus Type 1 Protease and Acetyl- Pepstatin at 2.0-angstroms Resolution
5757Hiv-1 Proteaseu101935 Complex
54880Design, Activity and 2.8 Angstroms Crystal Structure of a C2 Symmetric Inhibitor Complexed to Hiv-1 Protease