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MMDB Description
12182Hsp90 N-terminal Domain Bound to Adp-mg
23110Human Hsp90 in Complex With 17-desmethoxy-17-n,n- Dimethylaminoethylamino-geldanamycin
28386Human Hsp90-alpha With 9-butyl-8-(3,4,5-trimethoxy-benzyl)- 9h-purin-6-ylamine
28387Human Hsp90-alpha With 9-butyl-8-(4-methoxy-benzyl)-9h- Purin-6-ylamine
28388Human Hsp90-alpha With 9-butyl-8-(3-trimethoxy-benzyl)-9h-purin-6ylamine
28389Human Hsp90-alpha With 8-benzo[1,3]dioxol-,5-ylmethyl-9-butyl-9h-purin-6-ylamine
28390Human Hsp90-alpha With 9-butyl-8-(2,5-dimethoxy-benzyl)-9h-purin-6-ylamine
28391Human Hsp90-alpha With 9-butyl-8- (2-chloro-3,4,5-trimethoxy-benzyl)-9h-purin-6-ylamine
28392Human Hsp90-alpha With 8-(2-chloro-3,4,5-trimethoxy-benzyl)- 9-pent-4-ylnyl-9h-purin-6-ylamine
28393Human Hsp90-alpha With 8-(2-chloro-3,4,5-trimethoxy-benzyl) -2-fluoro-9-pent-4-ylnyl-9h-purin-6-ylamine
28394Human Hsp90-alpha With 8-(2,5-dimethoxy-benzyl)-2-fluoro-9h-purin-6-ylamine
28395Human Hsp90-alpha With 9-butyl-8-(2,5-dimethoxy-benzyl)-2- Fluoro-9h-purin-6-ylamine
31201Human Hsp90-alpha With 8-(2,5-dimethoxy-benzyl)-2-fluoro-9- Pent-9h-purin-6-ylamine
28397Human Hsp90-alpha With 8-benzo[1,3]dioxol-,5-ylmethyl-9-but Yl-2-fluoro-9h-purin-6-ylamine
28398Structure-activity Relationships in Purine-based Inhibitor Binding to Hsp90 Isoforms
29167Human Hsp90-beta With PU3 (9-butyl-8(3,4,5-trimethoxy- Benzyl)-9h-purin-6-ylamine)
32056Crystal Structures of Human Hsp90alpha Complexed With Dihydroxyphenylpyrazoles
32057Crystal Structure of Human Hsp90alpha Complexed With Dihydroxyphenylpyrazoles
32058Crystal Structure of Human Hsp90alpha Complexed With Dihydroxyphenylpyrazoles
52122Human Hsp90 Geldanamycin-binding Domain, "closed" Conformation
52123Human Hsp90 Geldanamycin-binding Domain, "open" Conformation
52124Geldanamycin Bound to the Hsp90 Geldanamycin-binding Domain
34017Novel, Potent Small Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered Through Structure-based Design
34019Novel, Potent Small Molecule Inhibitors of the Molecular Chaperone Hsp90 Discovered Through Structure-based Design
357643-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone
357653-(5-chloro-2,4-dihydroxyphenyl)-pyrazole-4-carboxamides as Inhibitors of the Hsp90 Molecular Chaperone
35771Structure-based Discovery of a NEW Class of Hsp90 Inhibitors
37644Human Hsp90 With 4-chloro-6-(4-piperazin-1-yl-1h-pyrazol-3- Yl)-benzene-1,2-diol
37645Human Hsp90 With 5-(5-chloro-2,4-dihydroxy-phenyl)-4- Piperazin-1-yl-2h-pyrazole-3-carboxylic Acid Ethylamide
37646Human Hsp90 With 4-chloro-6-(4-(4-(4-methanesulphonyl- Benzyl)-pierazin-1-yl)-1h-pyrazol-3-yl)-benzene-1,3-diol
41514Structure of Human Hsp90-alpha Bound to the Potent Water Soluble Inhibitor Pu-h64
41515Structure of Human Hsp90-alpha Bound to the Potent Water Soluble Inhibitor Pu-h71
41606Structure of Human Hsp90-alpha Bound to the Potent Water Soluble Inhibitor Pu-dz8
65429Hsp90 Alpha Atpase Domain With Bound Small Molecule Fragment
68330Human Cdc37-hsp90 Docking Model Based on NMR
65169Hsp90 Complexed With A56322
65170Hsp90 Complexed With A143571 and A516383
65175Hsp90 Complexed With A943037
65176Hsp90 Complexed With A917985
54332Inhibition of the Hsp90 Molecular Chaperone in Vitro and in Vivo by Novel, Synthetic, Potent Resorcinylic Pyrazole, Isoxazole Amide Analogs
612474,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
612484,5 Diaryl Isoxazole Hsp90 Chaperone Inhibitors: Potential Therapeutic Agents for the Treatment of Cancer
75543Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75544Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75545Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75546Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75547Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75548Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
75549Orally Active 2-amino Thienopyrimidine Inhibitors of the Hsp90 Chaperone
83922Structure of Hsp90 With an Inhibitor Bound
84508Structure of Hsp90 With Small Molecule Inhibitor Bound
84509Structure of Hsp90 With Small Molecule Inhibitor Bound
84510Structre of Hsp90 With Small Molecule Inhibitor Bound
84511Structre of Hsp90 With Small Molecule Inhibitor Bound
84512Structre of Hsp90 With Small Molecule Inhibitor Bound
84513Structure of Hsp90 With Small Molecule Inhibitor Bound
84514Structure of Hsp90 With Small Molecule Inhibitor Bound
84515Structure of Hsp90 With Small Molecule Inhibitor Bound
83933Structure of Hsp90 With Small Molecule Inhibitor Bound
83934Structre of Hsp90 With Small Molecule Inhibitor Bound
83935Structre of Hsp90 With Small Molecule Inhibitor Bound
84518Structre of Hsp90 With Small Molecule Inhibitor Bound
65387Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
65388Discovery of Benzisoxazoles as Potent Inhibitors of Chaperone Hsp90
65011Crystal Structure of Benzamide Tetrahydro-4h-carbazol-4-one Bound to Hsp90
68156Dihydroxylphenyl Amides as Inhibitors of the Hsp90 Molecular Chaperone
68157Dihydroxylphenyl Amides as Inhibitors of the Hsp90 Molecular Chaperone
72466Structure of Hsp90 Bound With a Novel Fragment
74958Structure of Hsp90 Bound With a Noval Fragment
77028Hsp90 N-terminal Domain in Complex With 1-{4-[(2r)-1-(5- Chloro-2,4-dihydroxybenzoyl)pyrrolidin-2-yl]benzyl}-3,3- Difluoropyrrolidinium
75332Human Heat-shock Protein 90 (Hsp90) in Complex With {4-[3- (2,4-dihydroxy-5-isopropyl-phenyl)-5-thioxo- 1,5-dihydro- [1,2,4]triazol-4-yl]-benzyl}-carbamic Acid Ethyl Ester {ZK 2819}
83294Crystal Structure of Hsp90 With Fragment 37-d04
83295Crystal Structure of Hsp90 With Fragment 42-c03
83296Crystal Structure of Hsp90 With Fragments 37-d04 and 42-c03
83297Crystal Structure of Hsp90 With Fragment Z064
84133Hsp90 N-terminal Domain With Pochoxime a
84134Hsp90 N-terminal Domain With Pochoxime B
79979Hsp90 N-terminal Domain in Complex With 4-chloro-6-{[(2r)-2- (2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol
79980Hsp90 N-terminal Domain in Complex With (1r)-2-(5-chloro-2, 4-dihydroxybenzoyl)-n-ethylisoindoline-1-carboxamide
79981Hsp90 N-terminal Domain in Complex With 4-(1,3-dihydro-2h- Isoindol-2-ylcarbonyl)benzene-1,3-diol
84013Crystal Structure of Benzamide Snx-1321 Bound to Hsp90
87463Hsp90b N-terminal Domain in Complex With Ec44, a Pyrrolo-pyrimidine Methoxypyridine Inhibitor
87396Crystal Structure of the Middle Domain of Human Hsp90-beta Refined at 2.3 Å Resolution
90997Crystal Structure of Human Mc-hsp90 in C2221 Space Group
90998Crystal Structure of Human Mc-hsp90 in P21 Space Group
89736Design and SAR of Macrocyclic Hsp90 Inhibitors With Increased Metabolic Stability and Potent Cell-proliferation Activity
90213Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4- Fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2- Difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide
90214Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4- Fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2- Difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide
90215Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4- Fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2- Difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide
90216Optimization of Potent, Selective, and Orally Bioavailable Pyrrolodinopyrimidine-containing Inhibitors of Heat Shock Protein 90. Identification of Development Candidate 2-amino-4-{4-chloro-2-[2-(4- Fluoro-1h-pyrazol-1-yl)ethoxy]-6-methylphenyl}-n-(2,2- Difluoropropyl)-5,7-dihydro-6h-pyrrolo[3,4-d]pyrimidine-6-carboxamide
90498Macrocyclic Lactams as Potent Hsp90 Inhibitors With Excellent Tumor Exposure and Extended Biomarker Activity
91246Discovery of a Macrocyclic O-aminobenzamide Hsp90 Inhibitor With Heterocyclic Tether That Shows Extended Biomarker Activity and in Vivo Efficacy in a Mouse Xenograft Model
91261Co-crystal Structure of the Hsp90 ATP Binding Domain in Complex With 4-(2,4-dichloro-5-methoxyphenyl)-6-methylpyrimidin-2-amine
91262Co-crystal Structure of the Hsp90 ATP Binding Domain in Complex With 4-(2,4-dichloro-5-methoxyphenyl)-2-methyl-7h-pyrrolo[2,3- D]pyrimidine-5- Carbonitrile
91263Co-crystal Structure of the Hsp90 ATP Binding Domain in Complex With 4-(2,4-dichloro-5-methoxyphenyl)-2,6-dimethyl-7h-pyrrolo[2,3- D]pyrimidine-5-carbonitrile