Abstract
Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacokinetics
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Antineoplastic Agents / pharmacology
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Antirheumatic Agents / chemical synthesis
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Antirheumatic Agents / pharmacokinetics
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Antirheumatic Agents / pharmacology
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Biological Availability
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Cartilage / drug effects
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Combinatorial Chemistry Techniques
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Drug Stability
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Humans
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Matrix Metalloproteinase Inhibitors*
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Mice
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Microsomes, Liver
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Neoplasm Metastasis / drug therapy
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Neoplasms, Experimental / drug therapy
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Propionates / chemical synthesis
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Propionates / pharmacokinetics
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Propionates / pharmacology*
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Proteoglycans / drug effects
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Proteoglycans / metabolism
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Structure-Activity Relationship
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Substrate Specificity
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Antirheumatic Agents
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Matrix Metalloproteinase Inhibitors
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Propionates
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Proteoglycans