Abstract
Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha-glucosidase was ascribed to the tether arm.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chromatography, High Pressure Liquid
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Enzyme Inhibitors / pharmacology*
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Geobacillus stearothermophilus / enzymology
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Glycoside Hydrolases / antagonists & inhibitors*
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Magnetic Resonance Spectroscopy
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Oryza / enzymology
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Saccharomyces cerevisiae / enzymology
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Structure-Activity Relationship
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Sulfonium Compounds / pharmacology*
Substances
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Enzyme Inhibitors
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Sulfonium Compounds
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Glycoside Hydrolases