Abstract
In parallel with our work on solution-phase parallel synthesis of ligands for the rotamase enzyme FKBP12, we herein report a methodology for the solid-phase synthesis of two classes of inhibitor, N-sulfonyl and N-carbamoylprolyl and pipecolyl amides along with their in vitro/in vivo biological results.
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Animals
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Carbamates / chemical synthesis*
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Carbamates / chemistry
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Carbamates / pharmacology
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Combinatorial Chemistry Techniques / methods
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Mice
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Models, Molecular
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Molecular Structure
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Parkinsonian Disorders / chemically induced
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Parkinsonian Disorders / enzymology
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Pipecolic Acids / chemical synthesis*
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Pipecolic Acids / chemistry
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Pipecolic Acids / pharmacology
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Structure-Activity Relationship
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Sulfonic Acids / chemical synthesis*
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Sulfonic Acids / chemistry
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Sulfonic Acids / pharmacology
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Tacrolimus Binding Proteins / antagonists & inhibitors*
Substances
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Carbamates
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Enzyme Inhibitors
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Pipecolic Acids
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Sulfonic Acids
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Tacrolimus Binding Proteins