Synthesis of imidazopyridines and purines as potent inhibitors of leukotriene A4 hydrolase

Bioorg Med Chem Lett. 2003 Mar 24;13(6):1137-9. doi: 10.1016/s0960-894x(03)00039-8.

Abstract

The synthesis and biological evaluation of a series of heterocyclic analogues of the previously reported LTA(4) hydrolase inhibitor 1b are described. Imidazopyridine and purine analogues are specifically highlighted with several demonstrating excellent potency in our in vitro assays, as well as good oral activity in a mouse ex vivo assay.

MeSH terms

  • Animals
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Epoxide Hydrolases / antagonists & inhibitors*
  • Epoxide Hydrolases / blood
  • Heterocyclic Compounds / chemical synthesis
  • Heterocyclic Compounds / pharmacology
  • Humans
  • In Vitro Techniques
  • Indicators and Reagents
  • Mice
  • Purines / chemical synthesis*
  • Purines / pharmacology*
  • Pyridines / chemical synthesis*
  • Pyridines / pharmacology*
  • Recombinant Proteins / antagonists & inhibitors
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • Heterocyclic Compounds
  • Indicators and Reagents
  • Purines
  • Pyridines
  • Recombinant Proteins
  • Epoxide Hydrolases
  • leukotriene A4 hydrolase