Abstract
High throughput screening combined with efficient datamining and parallel synthesis led to the discovery of a novel series of indolines showing potent in vitro ghrelin receptor agonist activity and acceleration of gastric emptying in rats.
MeSH terms
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Animals
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Gastric Emptying / drug effects
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Gastric Emptying / physiology
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Human Growth Hormone / agonists
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Humans
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Indoles / chemistry*
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Indoles / pharmacology
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Rats
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Receptors, Ghrelin / agonists*
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Receptors, Ghrelin / physiology
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Stereoisomerism
Substances
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Indoles
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Receptors, Ghrelin
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Human Growth Hormone
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indoline