Abstract
Chemical investigations of the tropical marine sponge Hyrtios sp. have resulted in the isolation of a new alkaloid, 1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline (1) together with the known metabolites, 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (2), 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), serotonin (4), hyrtiosin A (5), 5-hydroxyindole-3-carbaldehyde (6), and hyrtiosin B (7). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosin B (7) displayed a potent inhibitory activity against isocitrate lyase (ICL) of Candida albicans with an IC(50) value of 89.0 microM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Antifungal Agents / chemistry
-
Antifungal Agents / isolation & purification*
-
Antifungal Agents / pharmacology*
-
Candida albicans / enzymology*
-
Carbolines / chemistry
-
Carbolines / isolation & purification*
-
Carbolines / pharmacology
-
Indole Alkaloids / chemistry
-
Indole Alkaloids / isolation & purification*
-
Indole Alkaloids / pharmacology*
-
Isocitrate Lyase / antagonists & inhibitors*
-
Marine Biology
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Porifera / chemistry*
Substances
-
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline
-
5-hydroxyindole-3-carbaldehyde
-
Antifungal Agents
-
Carbolines
-
Indole Alkaloids
-
Isocitrate Lyase