Abstract
Proteases typically recognize their peptide substrates in extended conformations. General approaches for designing protease inhibitors often consist of peptidomimetics that feature this conformation. Herein we discuss a combination of computational and experimental studies to evaluate the potential of triazole-linked beta-strand mimetics as inhibitors of HIV-1 protease activity.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Anti-HIV Agents / chemistry*
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Anti-HIV Agents / pharmacology
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Catalytic Domain
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Computer Simulation
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HIV Protease / chemistry*
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HIV Protease / metabolism
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HIV Protease Inhibitors / chemistry*
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HIV Protease Inhibitors / pharmacology
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Humans
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Software
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Triazoles / chemistry*
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Triazoles / pharmacology
Substances
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Anti-HIV Agents
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HIV Protease Inhibitors
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Triazoles
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HIV Protease
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p16 protease, Human immunodeficiency virus 1