Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora

Koichiro Koyama; Yusuke Hirasawa; Takahiro Hosoya; Teh Chin Hoe; Kit-Lam Chan; Hiroshi Morita

doi:10.1016/j.bmc.2010.04.086

Alpneumines A-H, new anti-melanogenic indole alkaloids from Alstonia pneumatophora

Bioorg Med Chem. 2010 Jun 15;18(12):4415-21. doi: 10.1016/j.bmc.2010.04.086. Epub 2010 Apr 29.

Authors

Koichiro Koyama¹, Yusuke Hirasawa, Takahiro Hosoya, Teh Chin Hoe, Kit-Lam Chan, Hiroshi Morita

Affiliation

¹ Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo 142-8501, Japan.

PMID: 20576577
DOI: 10.1016/j.bmc.2010.04.086

Abstract

Eight new indole alkaloids, alpneumines A-H (1-8) were isolated from the Malaysian Alstonia pneumatophora (Apocynaceae) and their structures were determined by MS and 2D NMR spectroscopic methods. Alpneumines E and G (5 and 7), vincamine, and apovincamine showed anti-melanogenesis in B16 mouse melanoma cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alstonia / chemistry*
Animals
Antineoplastic Agents, Phytogenic / chemistry*
Antineoplastic Agents, Phytogenic / isolation & purification
Antineoplastic Agents, Phytogenic / therapeutic use
Indole Alkaloids / chemistry*
Indole Alkaloids / isolation & purification
Indole Alkaloids / therapeutic use
Magnetic Resonance Spectroscopy
Melanoma, Experimental / drug therapy
Mice
Molecular Conformation
Vincamine / analogs & derivatives
Vincamine / chemistry
Vincamine / therapeutic use

Substances

Antineoplastic Agents, Phytogenic
Indole Alkaloids
apovincamine
Vincamine