Abstract
A series of N-benzoyl-2-methylindole-3-acetic acids were synthesized and biologically evaluated as prostaglandin (PG) D₂ receptor antagonists. Some of the selected compounds significantly inhibited OVA-induced vascular permeability in guinea pig conjunctiva after oral dosing. Structure-activity relationship study is presented.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
-
Animals
-
CHO Cells
-
Capillary Permeability / drug effects*
-
Conjunctiva / blood supply
-
Cricetinae
-
Cricetulus
-
Drug Discovery
-
Guinea Pigs
-
Humans
-
Indoles / chemistry*
-
Indoles / pharmacology*
-
Receptors, Immunologic / antagonists & inhibitors*
-
Receptors, Immunologic / metabolism*
-
Receptors, Prostaglandin / antagonists & inhibitors*
-
Receptors, Prostaglandin / metabolism*
Substances
-
Indoles
-
Receptors, Immunologic
-
Receptors, Prostaglandin
-
prostaglandin D2 receptor