Abstract
Bioassay-guided fractionation of roots of Beilschmiedia tsangii led to the isolation of six new endiandric acid analogues: tsangibeilin A (1), tsangibeilin B (2), endiandramide A (3), endiandric acid K (4), endiandric acid L (5), and endiandramide B (6). Also isolated were two new lignans, beilschminol A (7) and tsangin C (8), and six known compounds. The structures of 1-8 were determined by spectroscopic techniques. Compounds 3 and 6 exhibited potent iNOS inhibitory activity, with IC(50) values of 9.59 and 16.40 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Carboxylic Acids / chemistry
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Carboxylic Acids / isolation & purification*
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Carboxylic Acids / pharmacology*
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Inhibitory Concentration 50
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Lauraceae / chemistry*
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Lignans / chemistry
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Lignans / isolation & purification
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Lignans / pharmacology
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nitric Oxide Synthase Type II / antagonists & inhibitors*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Roots / chemistry
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Taiwan
Substances
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Anti-Inflammatory Agents
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Carboxylic Acids
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Lignans
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endiandric acid
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Nitric Oxide
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Nitric Oxide Synthase Type II