Abstract
Two novel 2-arylbenzofuran dimers, morusyunnansins A and B (1 and 2), two new biflavonoids, morusyunnansins C and D (3 and 4), two new flavans, morusyunnansins E and F (5 and 6), and four known flavans (7-10) were isolated from the leaves of Morus yunnanensis. Compounds 5-8 showed potent inhibitory effects on mushroom tyrosinase with IC(50) values ranging from 0.12 ± 0.02 to 1.43 ± 0.43 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Agaricales / enzymology
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology
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Biflavonoids / chemistry
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Biflavonoids / isolation & purification*
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Biflavonoids / pharmacology
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Molecular Structure
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Monophenol Monooxygenase / antagonists & inhibitors*
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Morus / chemistry*
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Structure-Activity Relationship
Substances
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Benzofurans
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Biflavonoids
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Drugs, Chinese Herbal
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Flavonoids
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morusyunnansin A
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morusyunnansin B
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morusyunnansin C
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morusyunnansin D
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morusyunnansin E
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morusyunnansin F
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Monophenol Monooxygenase