Abstract
Anti-apoptotic B-cell lymphoma-2 (Bcl-2) proteins are promising targets for cancer therapy. In the present study, a series of imidazolidine-2,4-dione derivatives were designed and synthesized to test their inhibitory activities against anti-apoptotic Bcl-2 proteins. Among them, compound 8k had better growth inhibitory effects on K562 and PC-3 cell lines compared to lead compound WL-276.
Keywords:
Antitumor; Bcl-2; Imidazolidine-2,4-dione; Inhibitors.
Copyright © 2015 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Humans
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Hydantoins / chemical synthesis
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Hydantoins / pharmacology*
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Molecular Docking Simulation
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Myeloid Cell Leukemia Sequence 1 Protein / antagonists & inhibitors*
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Structure-Activity Relationship
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Sulfonamides / chemical synthesis
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Sulfonamides / pharmacology*
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Thiazoles / pharmacology
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bcl-X Protein / antagonists & inhibitors*
Substances
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Antineoplastic Agents
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Hydantoins
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Myeloid Cell Leukemia Sequence 1 Protein
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N-(4-chloro-3-nitrophenylsulfonyl)-2-(4-((3'-methylbiphenyl-4-yl)methyl)-2,5-dioxoimidazolidin-1-yl)-3-phenylpropanamide
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Sulfonamides
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Thiazoles
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WL 276
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bcl-X Protein