Discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridines as potent and selective SST5 agonists for the treatment of congenital hyperinsulinism

Bioorg Med Chem Lett. 2022 Sep 1:71:128807. doi: 10.1016/j.bmcl.2022.128807. Epub 2022 May 20.

Abstract

SST5 receptor activation potently inhibits insulin secretion from pancreatic β-cells, and an orally available nonpeptide selective SST5 agonist may be used to effectively manage the blood glucose levels of congenital HI patients to avoid severe hypoglycemia. Our medicinal chemistry efforts have led to the discovery of 4-(3-aminopyrrolidinyl)-3-aryl-5-(benzimidazol-2-yl)-pyridine analogs as potent SST5 agonists. This class of molecules exhibits excellent human SST5 potency and selectivity against SST1, SST2, SST3 and SST4 receptors. Leading compound 3-{4-[(3S)-3-aminopyrrolidin-1-yl]-5-(4-methyl-1H-1,3-benzodiazol-2-yl)pyridin-3-yl-5-fluorobenzonitrile (28, CRN02481) showed limited off-target activity and good pharmacokinetic profiles in both male Sprague Dawley rats and Beagle dogs to advance into further preclinical evaluations.

Keywords: Agonist; Congenital hyperinsulinism; Hypoglycemia; SST5 Receptor; Somatostatin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Congenital Hyperinsulinism* / drug therapy
  • Dogs
  • Humans
  • Male
  • Pyridines / pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Somatostatin / agonists
  • Somatostatin* / pharmacology
  • Somatostatin* / physiology

Substances

  • Pyridines
  • Receptors, Somatostatin
  • Somatostatin