Abstract
The 7-alkene-3-quinolinecarbonitrile 20, a potent inhibitor of Src enzymatic and cellular activity with IC(50) values of 2.1 and 58 nM, respectively, had comparable efficacy to bosutinib in a colon tumor xenograft study.
2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / pharmacology
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Humans
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Mice
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Mice, Nude
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Microsomes / metabolism
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Protein Kinase Inhibitors / chemical synthesis
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Protein Kinase Inhibitors / chemistry*
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Protein Kinase Inhibitors / pharmacology
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Quinolines / chemical synthesis
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Quinolines / chemistry*
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Quinolines / pharmacology
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Xenograft Model Antitumor Assays
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src-Family Kinases / antagonists & inhibitors*
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src-Family Kinases / metabolism
Substances
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Antineoplastic Agents
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Protein Kinase Inhibitors
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Quinolines
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src-Family Kinases