Abstract
Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V(1a) and V(2). Derivatives containing pyrrolo-tricyclic amines, 13i-k, 30, and 31 also showed selectivity for the V(2) receptor.
MeSH terms
-
Animals
-
Arginine Vasopressin / antagonists & inhibitors*
-
Benzazepines / chemical synthesis*
-
Benzazepines / pharmacology*
-
Dose-Response Relationship, Drug
-
Indicators and Reagents
-
Kidney Medulla / drug effects
-
Kidney Medulla / metabolism
-
Liver / drug effects
-
Liver / metabolism
-
Rats
-
Rats, Sprague-Dawley
-
Structure-Activity Relationship
-
Urodynamics / drug effects
Substances
-
Benzazepines
-
Indicators and Reagents
-
Arginine Vasopressin