Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin

S K Kalauni; M I Choudhary; F Shaheen; M D Manandhar; Atta-ur-Rahman; M B Gewali; A Khalid

doi:10.1021/np000466v

Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin

J Nat Prod. 2001 Jun;64(6):842-4. doi: 10.1021/np000466v.

Authors

S K Kalauni¹, M I Choudhary, F Shaheen, M D Manandhar, Atta-ur-Rahman, M B Gewali, A Khalid

Affiliation

¹ Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

PMID: 11421762
DOI: 10.1021/np000466v

Abstract

Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cholinesterase Inhibitors / chemistry*
Cholinesterase Inhibitors / isolation & purification
Cholinesterase Inhibitors / pharmacology*
Electrophorus
Horses
Magnetic Resonance Spectroscopy
Mass Spectrometry
Nepal
Plant Leaves / chemistry
Plants, Medicinal / chemistry*
Progesterone / analogs & derivatives
Progesterone / chemistry*
Progesterone / pharmacology*
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Cholinesterase Inhibitors
nepapakistamine A
vaganine D
Progesterone