Abstract
A new seven-membered lactone type meroterpenoid, isoterreulactone A, was isolated from the solid state fermentation of Aspergillus terreus and its structure was established by various spectral analysis. Isoterreulactone A inhibited acetylcholinesterase with an IC(50) value of 2.5 microM while did not inhibit butyrylcholinesterase even at 500 microM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholinesterase / metabolism*
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Aspergillus / chemistry*
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Butyrylcholinesterase / metabolism
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / metabolism
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Cholinesterase Inhibitors / pharmacology
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Fermentation
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Inhibitory Concentration 50
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Lactones / isolation & purification*
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Lactones / metabolism
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Lactones / pharmacology
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Terpenes / isolation & purification*
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Terpenes / metabolism
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Terpenes / pharmacology
Substances
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Cholinesterase Inhibitors
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Lactones
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Terpenes
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isoterreulactone A
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Acetylcholinesterase
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Butyrylcholinesterase