Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors

Huan Wen; Yayao Zhou; Chonglan Lin; Hui Ge; Lin Ma; Zihou Wang; Wenlie Peng; Huacan Song

doi:10.1016/j.bmcl.2007.01.091

Methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives: a new class of acetylcholinesterase inhibitors

Bioorg Med Chem Lett. 2007 Apr 15;17(8):2123-5. doi: 10.1016/j.bmcl.2007.01.091. Epub 2007 Feb 2.

Authors

Huan Wen¹, Yayao Zhou, Chonglan Lin, Hui Ge, Lin Ma, Zihou Wang, Wenlie Peng, Huacan Song

Affiliation

¹ School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.

PMID: 17317172
DOI: 10.1016/j.bmcl.2007.01.091

Abstract

A new class of inhibitors of acetylcholinesterase (methyl 2-(2-(4-formylphenoxy)acetamido)-2-substituted acetate derivatives) is described. Compounds 4b and 4i were found to be more potent than galanthamine in inhibiting acetylcholinesterase.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetates / chemical synthesis*
Acetates / pharmacology
Alzheimer Disease / drug therapy
Benzaldehydes / chemical synthesis*
Benzaldehydes / pharmacology
Cholinesterase Inhibitors / chemical synthesis*
Cholinesterase Inhibitors / pharmacology
Humans
Inhibitory Concentration 50
Structure-Activity Relationship

Substances

Acetates
Benzaldehydes
Cholinesterase Inhibitors
4-hydroxybenzaldehyde