Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities

Rosdayati A Ramli; Wilford Lie; Stephen G Pyne

doi:10.1021/np400978x

Alkaloids from the roots of Stichoneuron caudatum and their acetylcholinesterase inhibitory activities

J Nat Prod. 2014 Apr 25;77(4):894-901. doi: 10.1021/np400978x. Epub 2014 Mar 7.

Authors

Rosdayati A Ramli¹, Wilford Lie, Stephen G Pyne

Affiliation

¹ School of Chemistry, University of Wollongong , Wollongong, New South Wales 2522, Australia.

PMID: 24606395
DOI: 10.1021/np400978x

Abstract

Four new stichoneurine-type alkaloids, stichoneurines F and G (1-2) and sessilistemonamines E and F (3-4), have been isolated from the root extracts of Stichoneuron caudatum. The structures and relative configurations of these alkaloids have been determined by spectroscopic methods and molecular modeling experiments. Compounds 1-4 were tested for their acetylcholinesterase (AChE) inhibitory activities against human AChE. Compound 3 showed significant inhibitory activity with an IC50 value of 9.1±0.15 μM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology*
Cholinesterase Inhibitors / chemistry
Cholinesterase Inhibitors / isolation & purification*
Cholinesterase Inhibitors / pharmacology*
Humans
Inhibitory Concentration 50
Malaysia
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plant Roots / chemistry
Stemonaceae / chemistry*

Substances

Alkaloids
Cholinesterase Inhibitors