Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B

F C Peng

doi:10.1021/np9701236

Structure and anti-acetylcholinesterase activity of 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B

J Nat Prod. 1997 Aug;60(8):842-3. doi: 10.1021/np9701236.

Author

F C Peng¹

Affiliation

¹ Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Republic of China.

PMID: 9287420
DOI: 10.1021/np9701236

Abstract

The structure of a metabolite produced on incubation of territrem B (1) with rat liver microsomes has been established to be 4 alpha-(hydroxymethyl)-4 alpha-demethylterritrem B (5). Compound 5 was a potent inhibitor of electric eel acetylcholinesterase (AChE) (E.C. 3.1.1.7).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetylcholinesterase / drug effects
Animals
Cholinesterase Inhibitors / chemistry*
Cholinesterase Inhibitors / pharmacology*
Magnetic Resonance Spectroscopy
Male
Microsomes, Liver / metabolism
Mycotoxins / chemistry
Mycotoxins / pharmacology
Pyrans / chemistry*
Pyrans / pharmacology*
Rats
Rats, Wistar
Spectrometry, Mass, Fast Atom Bombardment
Structure-Activity Relationship
Torpedo

Substances

Cholinesterase Inhibitors
Mycotoxins
Pyrans
4-hydroxymethyl-4-demethylterritrem B
Acetylcholinesterase